Sulbutiamine (Arcalion)_ It is available for over-the-counter sale as a nutritional supplement

Sulbutiamine

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Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B₁). It is indicated for the treatment of asthenia.^[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats^[2] and patients of schizophrenia^[2] suggests that it is a nootropic.

Effects

Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.^[3]

Dosage

Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,^[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.

Sulbutiamine
Systematic ( IUPAC) name
[4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl- amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl- formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3- yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
Identifiers
CAS number	3286-46-2
ATC code	A11 DA02
PubChem	71124
Chemical data
Formula	C32 H46N8 O6S2
Mol. mass	702.89 g/mol
SMILES	search in eMolecules, PubChem
Synonyms	Arcalion, bisibuthiamine, youvitan
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	5 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

--
Dr Marwah